Comparative Analysis of Salivary Alpha-Amylase Enzyme Concentrations in Patients with Chronic Periodontitis and Rheumatoid Arthritis

Section: Research Paper
Issue
Vol. 26 No. 1 (2026): Volume 26 Issue 1
Pages
116-131

Keywords:

Alpha-amylase, Periodontitis, Rheumatoid arthritis

Abstract

Aims: The present study aimed to evaluate and contrast the concentrations of salivary alpha-amylase enzyme and the condition of periodontal health by the measurement of many clinical periodontal indicators, including plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL). The assessment will be carried out on several research cohorts, with an additional focus on investigating the association between alpha-amylase salivary enzyme levels and clinical periodontal parameters. Materials and Methods: A total of 150 participants, ranging in age from 25 to 65, were observed, and this cross-sectional research was conducted. The individuals were categorized into three distinct groups according to their periodontal health status: 50 individuals with periodontitis (stage II and III, grade B), 50 rheumatoid arthritis patients (male and female) with periodontitis, and 50 Individuals who have a periodontium that is in a state of clinical health and good overall medical health. Salivary alpha-amylase enzyme levels, GI, BOP, PPD, and CAL were recorded for all attendees. Results: The findings demonstrated substantial disparities between the research and control groups regarding clinical periodontal measures, including CAL, BOP score 1, GI, PLI, and PPD. The group with the most significant average alpha-amylase levels is Rheumatoid arthritis with periodontitis (stage II and III) (145.13). In contrast, the control group has the lowest average amylase value (77.32). The link between alpha-amylase and clinical periodontal parameters was virtually significant and positively correlated in three groups. Conclusion: Evaluating the amount of alpha-amylase in the saliva is believed to be an excellent biological indication for predicting the development of periodontal disease in individuals afflicted with rheumatoid arthritis. Therefore, this provides a solid notion of the influence that systemic illness has on the periodontal tissues.

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Author

Noor Sabah Irhayyim

Department of Periodontology, College of Dentistry, University of Tikrit, Tikrit, Iraq

Identifiers

DOI: 10.33899/rdentj.v26i1.60507

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