Miscellaneous Adverse Effects of Drugs in the Oral Cavity: A Review Study
Pages
327-341Abstract
The clinical manifestations of the adverse effects of drugs in the oral cavity are diverse. New therapeutic agents have revolutionized the treatment of various studies focusing on the basic clinical manifestations of oral drug reactions, such as ulcers, infections, xerostomia, lichenoid reactions, pigmentation, white lesions, hyperplasia, paresthesia, osteonecrosis, angioedema, and malignancy. Dentists who provide oral health care should be familiar with these assays because they will encounter them in their practice.
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References
- Teoh L, Moses G, McCullough MJ. A review and guide to drug-associated oral adverse effects, salivary and neurosensory reactions. Part 1. *J Oral Pathol Med*. 2019;48(7):626-636. doi: 10.1111/jop.12911.
- Grace D, Blandine V-B, Cedric Y. Clinical guidelines - Diagnosis and treatment manual for curative programs in hospitals and dispensaries. Guidance for prescribing. 2024. ISBN: 978-2-37585-253-8.
- Yuan A, Bin Woo S. Adverse drug events in the oral cavity. *Oral Surg Oral Med Oral Pathol Oral Radiol*. 2015; 119:3547. doi: org/10.1016/j.oooo.2014.09.009.
- Katzung BG. The Nature of Drugs & Drug Development & Regulation. In: Basic & Clinical Pharmacology, 4th Edition. 2018: p11-19.
- Gowdar IM, Alhaqbani MM, Almughirah AM, Basalem SA, Alsultan FI, Alkhathlan MR. Knowledge and Practice about Self-Medication for Oral Health Problems among Population in Riyadh Region, Saudi Arabia. *J Pharm Bioallied Sci*. 2021;13(Suppl 1): S246-S250. doi: 10.4103/jpbs.JPBS_702_20.
- Rathee M, Sapra A. Dental Caries. StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551699.
- Yeoh, SC., Hua, H., Yepes, J.F., Peterson, D.E. (2018). Oral Manifestations of Systemic Diseases and their Treatments. In: Farah, C., Balasubramaniam, R., McCullough, M. (eds) Contemporary Oral Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-28100.
- Bahar E, Yoon H. Lidocaine: A Local Anesthetic, Its Adverse Effects and Management. Medicina (Kaunas). 2021 Jul 30;57(8):782. doi: 10.3390/medicina57080782.
- Bailey, E., Tickle, M., Campbell, S. et al. Systematic review of patient safety interventions in dentistry. BMC Oral Health 15, 152 (2015). https://doi.org/10.1186/s12903-015-0136-1.
- Li L, Sun DL. Adverse effects of articaine versus lidocaine in pediatric dentistry: a meta-analysis. J Clin Pediatr Dent. 2023 Nov;47(6):21-29. doi: 10.22514/jocpd.2023.078.
- National Institutes of Health. Oral health in America: advances and challenges. Bethesda (MD): US Department of Health and Human Services, National Institutes of Health, National Institute of Dental and Craniofacial Research; 2021. Accessed February 23, 2022. https://www.nidcr.nih.gov/sites/default/files/2021-12/Oral-Health-in-America-Advances-and-Challenges.pdf
- Plackett B. Research round-up: oral health. Nature. 2021 Oct 27. doi: 10.1038/d41586-021-02927-3. Epub ahead of print. PMID: 34707269.
- Katebi K, Eslami H, Jabbari S. Prevalence and causes of self-medication for oral health problems: a systematic review and meta-analysis. BMC Oral Health. 2024 Sep 19;24(1):1115. doi: 10.1186/s12903-024-04900-8.
- Becker DE. Adverse drug reactions in dental practice. Anesth Prog. 2014 Spring;61(1):26-33; quiz 34. doi: 10.2344/0003-3006-61.1.26.
- SubbulakshmiP,RajendiranD.(2019).Druginduced Oral Health Problems: A Comprehensive Review - Journal of Oral Pathology & Medicine,8(10(B)): 20158-163.DOI:10.24327/ijcar.2019.20163.3929
- Vozza I. Oral Prevention and Management of Oral Healthcare. Int J Environ Res Public Health. 2021 Feb 18;18(4):1970. doi: 10.3390/ijerph18041970.
- Raed AlRowis, Abdulmalik Aldawood, Mohammed AlOtaibi, Essam Alnasser, Ibrahim AlSaif, Abdullah Aljaber, Zuhair Natto,Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review of Pathophysiology, Risk Factors, Preventive Measures and Treatment Strategies, The Saudi Dental Journal, Volume 34, Issue 3,2022, Pages 202-210,ISSN 1013-9052, https: //doi.org/10.1016/j.sdentj.2022.01.003.
- Yip DW, Gerriets V. Penicillin. [Updated 2024 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554560.
- Glick A, Sista V, Johnson C. Oral Manifestations of Commonly Prescribed Drugs. Am Fam Physician. 2020 Nov 15;102(10):613-621.
- Parmar, N., Thompson, G. Adverse Drug Reactions: Part 2 Oral Ulceration. BDJ Student 30, 26–27 (2023). https://doi.org/10.1038/s41406-022-0921-7.
- Katebi K, Eslami H, Jabbari S. Prevalence and causes of self-medication for oral health problems: a systematic review and meta-analysis. BMC Oral Health. 2024 Sep 19;24(1):1115. doi: 10.1186/s12903-024-04900-8.
- US Department of Health and Human Services. Oral health in America: a report of the Surgeon General. Rockville (MD): US Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health; 2000. Accessed February 23, 2022. https://www.nidcr.nih.gov/sites/default/files/2017-10/hck1ocv.%40www.surgeon.fullrpt.pdf
- Bailey E, Tickle M, Campbell S, et al. Systematic review of patient safety interventions in dentistry. BMC Oral Health. 2015; 15:152. doi:10.1186/s12903-015-0136-1.
- Thanoon AS, Al-Mashhadane FA. Relationship Between Vitamin D Deficiency and Chronic Periodontitis. *Georgian Medical News*. 2023;10(343).
- Conrads G, About I. Pathophysiology of Dental Caries. *Monogr Oral Sci*. 2018;27: 1-10. doi: 10.1159/000487826. PMID: 29794423.
- McCrae JC, Morrison EE, MacIntyre IM, Dear JW, Webb DJ. Long-term adverse effects of paracetamol - a review. *Br J Clin Pharmacol*. 2018;84(10):2218-2230. doi: 10.1111/bcp.13656.
- Salih OW, Al-Mashhadane FA, Hamed RS. Impact Of Vitamin D3 Supplementation on Dental Implant Stability. *Military Medical Science Letters*. 2023;92(2):141-147. doi: 10.31482/Mmsl.2022.035.
- Queremel Milani DA, Davis DD. Pain Management Medications. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560692.
- Kapourani A, Kontogiannopoulos KN, Manioudaki AE, Poulopoulos AK, Tsalikis L, Assimopoulou AN, Barmpalexis P. A Review on Xerostomia and Its Various Management Strategies: The Role of Advanced Polymeric Materials in the Treatment Approaches. *Polymers (Basel)*. 2022;14(5):850. doi: 10.3390/polym14050850.
- Mohandoss AA, Thavarajah R. Salivary Flow Alteration in Patients Undergoing Treatment for Schizophrenia: Disease-Drug-Target Gene/Protein Association Study for Side-effects. *J Oral Biol Craniofac Res*. 2019;9(3):286-293. doi: 10.1016/j.jobcr.2019.06.009.
- Gray SL, Perera S, Soverns T, Hanlon JT. Systematic Review and Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults: An Update. Drugs Aging. 2023 Nov;40(11):965-979. doi: 10.1007/s40266-023-01064-y.
- Hodkinson, A., Tyler, N., Ashcroft, D.M. et al. Preventable medication harm across health care settings: a systematic review and meta-analysis. BMC Med 18, 313 (2020). https://doi.org/10.1186/s12916-020-01774-9
- Zazzara MB, Palmer K, Vetrano DL, Carfì A, Onder G. Adverse drug reactions in older adults: a narrative review of the literature. Eur Geriatr Med. 2021 Jun;12(3):463-473. doi: 10.1007/s41999-021-00481-9. Epub 2021 Mar 18. Erratum in: Eur Geriatr Med. 2022 Feb;13(1):307. doi: 10.1007/s41999-021-00591-4.
- Katebi K, Eslami H, Jabbari S. Prevalence and causes of self-medication for oral health problems: a systematic review and meta-analysis. BMC Oral Health. 2024 Sep 19;24(1):1115. doi: 10.1186/s12903-024-04900-8.
- Bailey, E., Tickle, M., Campbell, S. et al. Systematic review of patient safety interventions in dentistry. BMC Oral Health 15, 152 (2015). https://doi.org/10.1186/s12903-015-0136-1.
- Akcaboy M, Sahin S, Zorlu P, Şenel S. Ranitidine-induced black tongue: A case report. *Pediatr Dermatol*. 2017 Nov;34(6). doi: 10.1111/pde.13309.
- 38. Lawoyin D, Brown RS. Drug-induced black hairy tongue: diagnosis and management challenges. Dent Today. 2008 Jan;27(1):60, 62-3
- Anna Yuan, Sook-Bin Woo,Adverse drug events in the oral cavity,Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,Volume 119, Issue 1,2015,Pages 35-47,ISSN 2212-4403,https://doi.org/10.1016/j.oooo.2014.09.009.
- Katebi K, Eslami H, Jabbari S. Prevalence and causes of self-medication for oral health problems: a systematic review and meta-analysis. BMC Oral Health. 2024 Sep 19;24(1):1115. doi: 10.1186/s12903-024-04900-8.
- Roberta G, Angelo VM, Francesco SMC. Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases. *J Clin Med*. 2019;8(1):21.https:// doi: org/10.3390/jcm8010021.
- Pugazhenthan T, Singh H, Kumar P, Hariharan B. Is dysgeusia going to be a rare or common side-effect of amlodipine? *Ann Med Health Sci Res*. 2014; 4:43-4. Available from: http://www.amhsr.org.
- Sigaux J, Mathieu S, Nguyen Y, Sanchez P, Letarouilly JG, Soubrier M, Czernichow S, Flipo RM, Sellam J, Daïen C. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis. Arthritis Res Ther. 2022 May 7;24(1):100. doi: 10.1186/s13075-022-02781-2.
- Nguyen, Y.; Sigaux, J.; Letarouilly, J.-G.; Sanchez, P.; Czernichow, S.; Flipo, R.-M.; Soubrier, M.; Semerano, L.; Seror, R.; Sellam, J.; et al. Efficacy of Oral Vitamin Supplementation in Inflammatory Rheumatic Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2021, 13, 107. https://doi.org/10.3390/nu13010107.
- Bonelli M, Kerschbaumer A, Kastrati K, Ghoreschi K, Gadina M, Heinz LX, Smolen JS, Aletaha D, O'Shea J, Laurence A. Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story. Ann Rheum Dis. 2024 Jan 11;83(2):139-160. doi: 10.1136/ard-2023-223850.
- Abdollahi M, Rahimi R, Radfar M. Current opinion on drug-induced oral reactions: a comprehensive review. *J Contemp Dent Pract*. 2008 Mar 1;9(3):1-15.
- Alfakje T H, Al-Mashhadane F A. (2024). Histopathological Effects of Anabolic Androgenic Steroids (Nandrolone Decanoate) on Heart, Liver, and Kidney of Male Local Rabbits. Egyptian Journal of Veterinary Sciences Vol. 55, (Special issue), pp. 1907-1919 (2024).
- Janas-Naze A, Osica P. The incidence of lidocaine allergy in dentists: An evaluation of 100 general dental practitioners. *Int J Occup Med Environ Health*. 2019;32(3):333-339. doi: https://doi.org/10.13075/ijomeh.1896.01235.
- Sambrook PJ, Smith W, Goss J. Severe adverse reactions to dental local anesthetics: systemic reactions. *Aust Dent J*. 2011; 56:148-153. doi: 10.1111/j.1834-7819.
- Bina B, Hersh E, Hilario M, Alvarez K, McLaughlin B. True Allergy to Aide Local Anesthetics: A Review and Case Presentation. *Anesth Prog*. 2018;65: 119-123. doi: j DOI 10.2344/anpr-65-03-06.
- Deguchi T, Abe R. Cutaneous Adverse Drug Reaction Caused by Antiepileptic Drug. *Brain Nerve*. 2019;71(4):401-406. doi: 10.11477/mf.1416201284.
- King G, Byrne A, Fleming P. A case of severe NSAID exacerbated respiratory disease (NERD) following a dental procedure in a child. *Eur Arch Paediatr Dent*. 2016;17(4):277-281. doi: 10.1007/s40368-016-0233-0.
- Rose MA, Garcez T, Savic S, Garvey LH. Chlorhexidine allergy in the perioperative setting: a narrative review. *Br J Anaesth*. 2019;123(1): e95-e103. doi: 10.1016/j.bja.2019.01.033.
- Kallus T, Mjör I. Incidence of adverse effects of dental materials. *Eur J Oral Sci*. 1991;99(3). doi: org/10.1111/j.1600-0722.1991. tb01890.x
- Kalogirou EM, Tosios KI. Fixed drug eruption on the tongue associated with piroxicam: report of two cases and literature review. *Oral Surg Oral Med Oral Pathol Oral Radiol*. 2019;127(5):393-398. doi: 10.1016/j.oooo.2019.01.073.
- Jinbu Y, Demitsu T. Oral ulcerations due to drug medications. *Jpn Dent Sci Rev*. 2014;50: 40-46.
- Gandhi RP, Klein U. Stevens-Johnson Syndrome: A Review and Report of Two Cases. *Pediatr Dent*. 2017;39(1):9-14.
- Dalia M, Yasmine K, Ashraf HH, Amal A. Prevalence of oral side effects associated with chemo and radiotherapy in head and neck cancer treatment: A cross-sectional study in Egypt. *Oral Oncol Rep*. 2024; 10:100177.
- González-Arriagada WA, Ottaviani G, Dean D, Ottaviani G, Santos-Silva AR, Treister NS. Oral complications in cancer patients. *Front Oral Health*. 2023;3: 1116885.
- Kommu S, Carter C, Whitfield P. Adverse Drug Reactions. [Updated 2024 Jan 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK599521/,
- Caron P, Grunenwald S, Persani L, Borson-Chazot F, Leroy R, Duntas L.Rev Endocr Metab Disord. 2022 Jun;23(3):463-483. doi: 10.1007/s11154-021-09691-9. Epub 2021 Oct 20. PMID: 34671932
- Padayachee N, Matesun D, Matlala M, Vagiri R. Adverse drug reactions, a guide for dentists. *S Afr Dent J*. 2023;78(1):32-36.
- Tawfik NO, Atarbashe RKH. Amlodipine and oral health. Al-Rafidain Dent J. 2014;14(1):111-114.
- Rapone B, Ferrara E, Santacroce L, Cesarano F, Arazzi M, Liberato LD, Scacco S, Grassi R, Grassi FR, Gnoni A, Nardi GM. Periodontal Microbiological Status Influences the Occurrence of Cyclosporine-A and Tacrolimus-Induced Gingival Overgrowth. *Antibiotics (Basel)*. 2019;8(3): E124.
- Gopinath S, Harishkumar VV, Santhosh VC, Puthalath S. Case report on a low dose of Cilnidipine: A fourth-generation calcium channel blocker-induced gingival overgrowth. J Indian Soc Periodontol. 2019;23(4):377-380.
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